Congeners of SMAP29 Kill Ovine Pathogens and Induce Ultrastructural Damage in Bacterial Cells

SMAP29, an ovine cathelicidin, was systematically altered to create a family of 23 related peptides for MIC and minimum bactericidal concentration determinations. SMAP28, SMAP29, and a derivative of SMAP29 called ovispirin were all antimicrobial. However, many congeners of SMAP29 and ovispirin were...

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Detalhes bibliográficos
Main Authors: Kalfa, V. C., Jia, H. P., Kunkle, R. A., McCray, P. B., Tack, B. F., Brogden, K. A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90821/
https://ncbi.nlm.nih.gov/pubmed/11600395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.11.3256-3261.2001
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