Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

Candida albicans and Cryptococcus neoformans cause both superficial and disseminated infections in humans. Current antifungal therapies for deep-seated infections are limited to amphotericin B, flucytosine, and azoles. A limitation is that commonly used azoles are fungistatic in vitro and in vivo. O...

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Main Authors: Cruz, M. Cristina, Goldstein, Alan L., Blankenship, Jill, Del Poeta, Maurizio, Perfect, John R., McCusker, John H., Bennani, Youssef L., Cardenas, Maria E., Heitman, Joseph
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2001
Ábhair:
Mechanisms of Action: Physiological Effects
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC90798/
https://ncbi.nlm.nih.gov/pubmed/11600372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.11.3162-3170.2001
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