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Rapamycin and Less Immunosuppressive Analogs Are Toxic to Candida albicans and Cryptococcus neoformans via FKBP12-Dependent Inhibition of TOR

Candida albicans and Cryptococcus neoformans cause both superficial and disseminated infections in humans. Current antifungal therapies for deep-seated infections are limited to amphotericin B, flucytosine, and azoles. A limitation is that commonly used azoles are fungistatic in vitro and in vivo. O...

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Published in:Antimicrob Agents Chemother
Main Authors: Cruz, M. Cristina, Goldstein, Alan L., Blankenship, Jill, Del Poeta, Maurizio, Perfect, John R., McCusker, John H., Bennani, Youssef L., Cardenas, Maria E., Heitman, Joseph
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2001
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90798/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11600372/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.11.3162-3170.2001
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