Cellular Uptake of Two Fluoroketolides, HMR 3562 and HMR 3787, by Human Polymorphonuclear Neutrophils In Vitro

We analyzed the cellular accumulation of two new fluoroketolides, HMR 3562 and HMR 3787, by human polymorphonuclear neutrophils (PMN) in vitro. Both compounds were rapidly taken up by PMN, with a cellular-to-extracellular concentration ratio (C/E) of about 141 (HMR 3562) and 117 (HMR 3787) at 5 min,...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Abdelghaffar, H., Vazifeh, D., Labro, M. T.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90734/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11557472/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.10.2798-2806.2001
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