Limonene Arrests Parasite Development and Inhibits Isoprenylation of Proteins in Plasmodium falciparum

Isoprenylation is an essential protein modification in eukaryotic cells. Herein, we report that in Plasmodium falciparum, a number of proteins were labeled upon incubation of intraerythrocytic forms with either [(3)H]farnesyl pyrophosphate or [(3)H]geranylgeranyl pyrophosphate. By thin-layer chromat...

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Главные авторы: Moura, Ivan Cruz, Wunderlich, Gerhard, Uhrig, Maria L., Couto, Alicia S., Peres, Valnice J., Katzin, Alejandro M., Kimura, Emília A.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2001
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Mechanisms of Action: Physiological Effects
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC90691/
https://ncbi.nlm.nih.gov/pubmed/11502528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.9.2553-2558.2001
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