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The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in <named-content content-type="genus-species">Plasmodium falciparum</named-content>

ABSTRACT Members of the haloacid dehalogenase (HAD) family of metabolite phosphatases play an important role in regulating multiple pathways in Plasmodium falciparum central carbon metabolism. We show that the P. falciparum HAD protein, phosphoglycolate phosphatase (PGP), regulates glycolysis and pe...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Laure Dumont, Mark B. Richardson, Phillip van der Peet, Danushka S. Marapana, Tony Triglia, Matthew W. A. Dixon, Alan F. Cowman, Spencer J. Williams, Leann Tilley, Malcolm J. McConville, Simon A. Cobbold
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019-12-01
Schriftenreihe:mBio
Schlagworte:
CRISPR
Plasmodium falciparum
antimalarial
fosmidomycin
glycolysis
isoprenoid
Online-Zugang:https://journals.asm.org/doi/10.1128/mBio.02060-19
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