N-Terminal Fatty Acid Substitution Increases the Leishmanicidal Activity of CA(1-7)M(2-9), a Cecropin-Melittin Hybrid Peptide

In order to improve the leishmanicidal activity of the synthetic cecropin A-melittin hybrid peptide CA(1-7)M(2-9) (KWKLFKKIGAVLKVL-NH(2)), a systematic study of its acylation with saturated linear fatty acids was carried out. Acylation of the N(ɛ)-7 lysine residue led to a drastic decrease in leishm...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Chicharro, Cristina, Granata, Cesare, Lozano, Rosario, Andreu, David, Rivas, Luis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2001
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90675/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11502512/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.9.2441-2449.2001
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