Safety and Bactericidal Activity of Rifalazil in Patients with Pulmonary Tuberculosis

Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy voluntee...

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Main Authors: Dietze, Reynaldo, Teixeira, Luciléia, Rocha, Lia Márcia Canedo, Palaci, Moisés, Johnson, John L., Wells, Charles, Rose, Lynn, Eisenach, Kathleen, Ellner, Jerrold J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Clinical Therapeutics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC90587/
https://ncbi.nlm.nih.gov/pubmed/11408210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.7.1972-1976.2001
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