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Safety and Bactericidal Activity of Rifalazil in Patients with Pulmonary Tuberculosis

Rifalazil, also known as KRM-1648 or benzoxazinorifamycin, is a new semisynthetic rifamycin with a long half-life of approximately 60 h. Rifalazil has potent bactericidal activity against Mycobacterium tuberculosis in vitro and in animal models of tuberculosis (TB). Prior studies in healthy voluntee...

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Publicado no:Antimicrob Agents Chemother
Principais autores: Dietze, Reynaldo, Teixeira, Luciléia, Rocha, Lia Márcia Canedo, Palaci, Moisés, Johnson, John L., Wells, Charles, Rose, Lynn, Eisenach, Kathleen, Ellner, Jerrold J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2001
Assuntos:
Clinical Therapeutics
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90587/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11408210/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.7.1972-1976.2001
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