Population Pharmacokinetics of Intramuscular Quinine in Children with Severe Malaria

We present the first population pharmacokinetic analysis of quinine in patients with Plasmodium falciparum malaria. Ghanaian children (n = 120; aged 12 months to 10 years) with severe malaria received an intramuscular loading dose of quinine dihydrochloride (20 mg/kg of body weight). A two-compartme...

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Bibliografiske detaljer
Main Authors: Krishna, Sanjeev, Nagaraja, Nelamangala V., Planche, Tim, Agbenyega, Tsiri, Bedo-Addo, George, Ansong, Daniel, Owusu-Ofori, Alex, Shroads, Albert L., Henderson, George, Hutson, Alan, Derendorf, Hartmut, Stacpoole, Peter W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2001
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90549/
https://ncbi.nlm.nih.gov/pubmed/11353629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.6.1803-1809.2001
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