Contributions of the 8-Methoxy Group of Gatifloxacin to Resistance Selectivity, Target Preference, and Antibacterial Activity against Streptococcus pneumoniae

Gatifloxacin (8-methoxy, 7-piperazinyl-3′-methyl) at the MIC selected mutant strains that possessed gyrA mutations at a low frequency (3.7 × 10(−9)) from wild-type strain Streptococcus pneumoniae IID553. AM-1147 (8-methoxy, 7-piperazinyl-3′-H) at the MIC or higher concentrations selected no mutant s...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Fukuda, Hideyuki, Kishii, Ryuta, Takei, Masaya, Hosaka, Masaki
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Mechanisms of Action: Physiological Effects
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90527/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.6.1649-1653.2001
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