Alkylglycerol Prodrugs of Phosphonoformate Are Potent In Vitro Inhibitors of Nucleoside-Resistant Human Immunodeficiency Virus Type 1 and Select for Resistance Mutations That Suppress Zidovudine Resistance

Phosphonoformate (foscarnet; PFA) is a potent inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), but its use for the treatment of HIV-1 infection is limited by toxicity and the lack of an orally bioavailable formulation. Alkylglycerol-conjugated prodrugs of PFA (1-O...

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Autori principali: Hammond, Jennifer L., Koontz, Dianna L., Bazmi, Holly Z., Beadle, James R., Hostetler, Saskia E., Kini, Ganesh D., Aldern, Kathy A., Richman, Douglas D., Hostetler, Karl Y., Mellors, John W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90523/
https://ncbi.nlm.nih.gov/pubmed/11353603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.6.1621-1628.2001
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