Activities and Conformational Fitting of 1,4-Naphthoquinone Derivatives and Other Cyclic 1,4-Diones Tested In Vitro against Pneumocystis carinii

Atovaquone is a chemotherapeutic agent used to treat pneumonia caused by Pneumocystis carinii in some immunocompromised patients. A set of cyclic 1,4-diones were tested in vitro for ability to inhibit growth of P. carinii, including 22 variously substituted 1,4-naphthoquinones, one bis-1,4-naphthoqu...

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Autori principali: Ball, M. D., Bartlett, M. S., Shaw, M., Smith, J. W., Nasr, M., Meshnick, S. R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90491/
https://ncbi.nlm.nih.gov/pubmed/11302813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.5.1473-1479.2001
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