Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Genetics of dTDP-Rhamnose Synthetic Enzymes and Development of a Microtiter Plate-Based Screen for Inhibitors of Conversion of dTDP-Glucose to dTDP-Rhamnose

An l-rhamnosyl residue plays an essential structural role in the cell wall of Mycobacterium tuberculosis. Therefore, the four enzymes (RmlA to RmlD) that form dTDP-rhamnose from dTTP and glucose-1-phosphate are important targets for the development of new tuberculosis therapeutics. M. tuberculosis g...

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izdano v:	Antimicrob Agents Chemother
Principais autores:	Ma, Yufang, Stern, Richard J., Scherman, Michael S., Vissa, Varalakshmi D., Yan, Wenxin, Jones, Victoria Cox, Zhang, Fangqiu, Franzblau, Scott G., Lewis, Walter H., McNeil, Michael R.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2001
Teme:	Mechanisms of Action: Physiological Effects
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90481/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11302803/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.5.1407-1416.2001
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