Drug Targeting Mycobacterium tuberculosis Cell Wall Synthesis: Genetics of dTDP-Rhamnose Synthetic Enzymes and Development of a Microtiter Plate-Based Screen for Inhibitors of Conversion of dTDP-Glucose to dTDP-Rhamnose

An l-rhamnosyl residue plays an essential structural role in the cell wall of Mycobacterium tuberculosis. Therefore, the four enzymes (RmlA to RmlD) that form dTDP-rhamnose from dTTP and glucose-1-phosphate are important targets for the development of new tuberculosis therapeutics. M. tuberculosis g...

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Autores principales: Ma, Yufang, Stern, Richard J., Scherman, Michael S., Vissa, Varalakshmi D., Yan, Wenxin, Jones, Victoria Cox, Zhang, Fangqiu, Franzblau, Scott G., Lewis, Walter H., McNeil, Michael R.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC90481/
https://ncbi.nlm.nih.gov/pubmed/11302803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.5.1407-1416.2001
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