In Vivo Efficacy of Trovafloxacin against Bacteroides fragilis in Mixed Infection with either Escherichia coli or a Vancomycin-Resistant Strain of Enterococcus faecium in an Established-Abscess Murine Model

The pharmacodynamic and pharmacokinetic properties of trovafloxacin were studied in a standardized murine model of established subcutaneous abscesses. Daily dosing regimens of 37.5 to 300 mg/kg every 8 h (q8h) or every 24 h (q24h) were started 3 days after inoculation with mixtures containing either...

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Hlavní autoři: Stearne, Lorna E. T., Gyssens, Inge C., Goessens, Wil H. F., Mouton, Johan W., Oyen, Wim J. G., van der Meer, Jos W. M., Verbrugh, Henri A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2001
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC90479/
https://ncbi.nlm.nih.gov/pubmed/11302801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.5.1394-1401.2001
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