Inhibition of Isoniazid-Induced Expression of Mycobacterium tuberculosis Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials

Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may f...

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Main Authors: Wallis, Robert S., Phillips, Manijeh, Johnson, John L., Teixeira, Luciléia, Rocha, Lia Márcia Massini Canedo, Maciel, Ethel, Rose, Lynn, Wells, Charles, Palaci, Moisés, Dietze, Reynaldo, Eisenach, Kathleen, Ellner, Jerrold J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Clinical Therapeutics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC90462/
https://ncbi.nlm.nih.gov/pubmed/11257053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.4.1302-1304.2001
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