New Mutation in ParE in a Pneumococcal In Vitro Mutant Resistant to Fluoroquinolones

For an in vitro mutant of Streptococcus pneumoniae selected on moxifloxacin four- to eightfold-increased MICs of new fluoroquinolones, only a twofold-increased MIC of ciprofloxacin, and a twofold-decreased MIC of novobiocin were observed. This phenotype was conferred by two mutations: Ser81Phe in Gy...

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Bibliographic Details
Main Authors: Janoir, Claire, Varon, Emmanuelle, Kitzis, Marie-Dominique, Gutmann, Laurent
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Mechanisms of Resistance
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90402/
https://ncbi.nlm.nih.gov/pubmed/11181389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.3.952-955.2001
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