Cyclopentane Neuraminidase Inhibitors with Potent In Vitro Anti-Influenza Virus Activities

A novel series of cyclopentane derivatives have been found to exhibit potent and selective inhibitory effects on influenza virus neuraminidase. These compounds, designated RWJ-270201, BCX-1827, BCX-1898, and BCX-1923, were tested in parallel with zanamivir and oseltamivir carboxylate against a spect...

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Autors principals: Smee, Donald F., Huffman, John H., Morrison, Ann C., Barnard, Dale L., Sidwell, Robert W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC90367/
https://ncbi.nlm.nih.gov/pubmed/11181354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.3.743-748.2001
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