Compartmental Pharmacokinetics of the Antifungal Echinocandin Caspofungin (MK-0991) in Rabbits

The pharmacokinetics of the antifungal echinocandin-lipopeptide caspofungin (MK-0991) in plasma were studied in groups of three healthy rabbits after single and multiple daily intravenous administration of doses of 1, 3, and 6 mg/kg of body weight. Concentrations were measured by a validated high-pe...

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Bibliographic Details
Main Authors: Groll, Andreas H., Gullick, Bryan M., Petraitiene, Ruta, Petraitis, Vidmantas, Candelario, Myrna, Piscitelli, Stephen C., Walsh, Thomas J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90333/
https://ncbi.nlm.nih.gov/pubmed/11158761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.596-600.2001
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