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Emergence of Multiple Human Cytomegalovirus Ganciclovir-Resistant Mutants with Deletions and Substitutions within the UL97 Gene in a Patient with Severe Combined Immunodeficiency

Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Wolf, Dana G., Yaniv, Isaac, Ashkenazi, Shai, Honigman, Alik
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90332/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158760/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.593-595.2001
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