Dosage-Dependent Antifungal Efficacy of V-Echinocandin (LY303366) against Experimental Fluconazole-Resistant Oropharyngeal and Esophageal Candidiasis

V-echinocandin (VER-002; LY303366) is a semisynthetic derivative of echinocandin B and a potent inhibitor of fungal (1, 3)-β-d-glucan synthase. We studied the antifungal efficacy, the concentrations in saliva and tissue, and the safety of VER-002 at escalating dosages against experimental oropharyng...

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Detalhes bibliográficos
Main Authors: Petraitis, Vidmantas, Petraitiene, Ruta, Groll, Andreas H., Sein, Tin, Schaufele, Robert L., Lyman, Caron A., Francesconi, Andrea, Bacher, John, Piscitelli, Stephen C., Walsh, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90315/
https://ncbi.nlm.nih.gov/pubmed/11158743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.471-479.2001
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