Validation of a Noninvasive, Real-Time Imaging Technology Using Bioluminescent Escherichia coli in the Neutropenic Mouse Thigh Model of Infection

A noninvasive, real-time detection technology was validated for qualitative and quantitative antimicrobial treatment applications. The lux gene cluster of Photorhabdus luminescens was introduced into an Escherichia coli clinical isolate, EC14, on a multicopy plasmid. This bioluminescent reporter bac...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Rocchetta, H. L., Boylan, C. J., Foley, J. W., Iversen, P. W., LeTourneau, D. L., McMillian, C. L., Contag, P. R., Jenkins, D. E., Parr, T. R.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Analytical Procedures
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90250/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11120955/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.1.129-137.2001
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