Influence of Human Serum on Pharmacodynamic Properties of an Investigational Glycopeptide, LY333328, and Comparator Agents against Staphylococcus aureus

The MICs and MBCs of 15 antibiotics for two strains of Staphylococcus aureus were determined in Mueller-Hinton broth (MHB) and 90% serum–10% MHB. Subsequent experiments established that highly protein-bound antibiotics (≥80%), such as LY333328, demonstrated higher MICs and MBCs, less killing over an...

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Autori principali: Zhanel, George G., Kirkpatrick, Iain D. C., Hoban, Daryl J., Kabani, Amin M., Karlowsky, James A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 1998
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC105846/
https://ncbi.nlm.nih.gov/pubmed/9736576
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