Influence of Human Serum on Pharmacodynamic Properties of an Investigational Glycopeptide, LY333328, and Comparator Agents against Staphylococcus aureus

The MICs and MBCs of 15 antibiotics for two strains of Staphylococcus aureus were determined in Mueller-Hinton broth (MHB) and 90% serum–10% MHB. Subsequent experiments established that highly protein-bound antibiotics (≥80%), such as LY333328, demonstrated higher MICs and MBCs, less killing over an...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Zhanel, George G., Kirkpatrick, Iain D. C., Hoban, Daryl J., Kabani, Amin M., Karlowsky, James A.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Susceptibility
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105846/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736576/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.9.2427
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