Anti-Epstein-Barr Virus (EBV) Activity of β-l-5-Iododioxolane Uracil Is Dependent on EBV Thymidine Kinase

β-l-5-Iododioxolane uracil was shown to have potent anti-Epstein-Barr virus (EBV) activity (50% effective concentration = 0.03 μM) with low cytotoxicity (50% cytotoxic concentration = 1,000 μM). It exerts its antiviral activity by suppressing replicative EBV DNA and viral protein synthesis. This com...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Kira, Toshihiko, Grill, Susan P., Dutschman, Ginger E., Lin, Ju-Sheng, Qu, Fucheng, Choi, Yongseok, Chu, Chung K., Cheng, Yung-Chi
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Antiviral Agents
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90192/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11083627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.12.3278-3284.2000
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