Anti-Epstein-Barr Virus (EBV) Activity of β-l-5-Iododioxolane Uracil Is Dependent on EBV Thymidine Kinase

β-l-5-Iododioxolane uracil was shown to have potent anti-Epstein-Barr virus (EBV) activity (50% effective concentration = 0.03 μM) with low cytotoxicity (50% cytotoxic concentration = 1,000 μM). It exerts its antiviral activity by suppressing replicative EBV DNA and viral protein synthesis. This com...

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Detalhes bibliográficos
Main Authors: Kira, Toshihiko, Grill, Susan P., Dutschman, Ginger E., Lin, Ju-Sheng, Qu, Fucheng, Choi, Yongseok, Chu, Chung K., Cheng, Yung-Chi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2000
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC90192/
https://ncbi.nlm.nih.gov/pubmed/11083627
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