Anti-Toxoplasma Activities of 24 Quinolones and Fluoroquinolones In Vitro: Prediction of Activity by Molecular Topology and Virtual Computational Techniques

The apicoplast, a plastid-like organelle of Toxoplasma gondii, is thought to be a unique drug target for quinolones. In this study, we assessed the in vitro activity of quinolones against T. gondii and developed new quantitative structure-activity relationship models able to predict this activity. T...

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Главные авторы: Gozalbes, Rafael, Brun-Pascaud, Monique, Garcia-Domenech, Ramon, Galvez, Jorge, Girard, Pierre-Marie, Doucet, Jean-Pierre, Derouin, Francis
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Microbiology 2000
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Mechanisms of Action: Physiological Effects
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC90150/
https://ncbi.nlm.nih.gov/pubmed/10991859
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