Contribution of Natural Amino Acid Substitutions in SHV Extended-Spectrum β-Lactamases to Resistance against Various β-Lactams

SHV extended-spectrum β-lactamases (ESBLs) arise through single amino acid substitutions in the parental enzyme, SHV-1. In order to evaluate the effect of genetic dissimilarities around the structural gene on MICs, we had previously devised an isogenic system of strains. Here, we present an extended...

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Bibliografiska uppgifter
Huvudupphovsmän: Randegger, Corinne C., Keller, André, Irla, Michel, Wada, Akihito, Hächler, Herbert
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2000
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC90148/
https://ncbi.nlm.nih.gov/pubmed/10991857
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