Contribution of Natural Amino Acid Substitutions in SHV Extended-Spectrum β-Lactamases to Resistance against Various β-Lactams

SHV extended-spectrum β-lactamases (ESBLs) arise through single amino acid substitutions in the parental enzyme, SHV-1. In order to evaluate the effect of genetic dissimilarities around the structural gene on MICs, we had previously devised an isogenic system of strains. Here, we present an extended...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Randegger, Corinne C., Keller, André, Irla, Michel, Wada, Akihito, Hächler, Herbert
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90148/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10991857/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.10.2759-2763.2000
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