Comparative Pharmacodynamic Analysis of Q-T Interval Prolongation Induced by the Macrolides Clarithromycin, Roxithromycin, and Azithromycin in Rats

In order to evaluate the arrhythmogenic potency of macrolide antibiotics in a quantitative manner, we analyzed the influence of clarithromycin (CAM), roxithromycin (RXM), and azithromycin (AZM) on Q-T intervals from pharmacokinetic and pharmacodynamic points of view and in comparison with the potenc...

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Bibliographic Details

Published in:	Antimicrob Agents Chemother
Main Authors:	Ohtani, Hisakazu, Taninaka, Chieko, Hanada, Erika, Kotaki, Hajime, Sato, Hitoshi, Sawada, Yasufumi, Iga, Tatsuji
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2000
Subjects:	Pharmacology
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10991836/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.10.2630-2637.2000
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