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Biochemical-Genetic Characterization and Distribution of OXA-22, a Chromosomal and Inducible Class D β-Lactamase from Ralstonia (Pseudomonas) pickettii

From genomic DNA of Ralstonia pickettii isolate PIC-1, a β-lactamase gene was cloned that encodes the oxacillinase OXA-22. It differs from known oxacillinases, being most closely related to OXA-9 (38% amino acid identity). The hydrolytic spectrum of OXA-22 is limited mostly to benzylpenicillin, clox...

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Main Authors: Nordmann, Patrice, Poirel, Laurent, Kubina, Maryline, Casetta, Anne, Naas, Thierry
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC90041/
https://ncbi.nlm.nih.gov/pubmed/10898703
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