Amino Acid Substitutions in a Variant of IMP-1 Metallo-β-Lactamase

In the course of surveying for the carbapenem-hydrolyzing metallo-β-lactamase gene bla(IMP) in pathogenic bacteria by the PCR method, we detected a gene encoding a variant metallo-β-lactamase, designated IMP-3, which differed from IMP-1 by having low hydrolyzing activity for penicillins and carbapen...

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Main Authors: Iyobe, Shizuko, Kusadokoro, Haruko, Ozaki, Junko, Matsumura, Naoki, Minami, Shinzaburo, Haruta, Shin, Sawai, Tetsuo, O'Hara, Koji
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Mechanisms of Resistance
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC90008/
https://ncbi.nlm.nih.gov/pubmed/10898670
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