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Role of Permeability in the Activities of β-Lactams against Gram-Negative Bacteria Which Produce a Group 3 β-Lactamase

The production of a group 3 β-lactamase permitted Escherichia coli to raise the MICs of ceftazidime, cefpirome, and meropenem greatly but those of imipenem and piperacillin only slightly. The ratios of maximum rate of hydrolysis to K(m) of ceftazidime, cefpirome, and piperacillin were lower than tho...

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Detalhes bibliográficos
Main Authors: Matsumura, Naoki, Minami, Shinzaburo, Watanabe, Yasuo, Iyobe, Shizuko, Mitsuhashi, Susumu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89422/
https://ncbi.nlm.nih.gov/pubmed/10428944
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