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Role of Permeability in the Activities of β-Lactams against Gram-Negative Bacteria Which Produce a Group 3 β-Lactamase

The production of a group 3 β-lactamase permitted Escherichia coli to raise the MICs of ceftazidime, cefpirome, and meropenem greatly but those of imipenem and piperacillin only slightly. The ratios of maximum rate of hydrolysis to K(m) of ceftazidime, cefpirome, and piperacillin were lower than tho...

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Autors principals: Matsumura, Naoki, Minami, Shinzaburo, Watanabe, Yasuo, Iyobe, Shizuko, Mitsuhashi, Susumu
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC89422/
https://ncbi.nlm.nih.gov/pubmed/10428944
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