Peptide Deformylase in Staphylococcus aureus: Resistance to Inhibition Is Mediated by Mutations in the Formyltransferase Gene

Peptide deformylase, a bacterial enzyme, represents a novel target for antibiotic discovery. Two deformylase homologs, defA and defB, were identified in Staphylococcus aureus. The defA homolog, located upstream of the transformylase gene, was identified by genomic analysis and was cloned from chromo...

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Dades bibliogràfiques

Publicat a:	Antimicrob Agents Chemother
Autors principals:	Margolis, Peter S., Hackbarth, Corinne J., Young, Dennis C., Wang, Wen, Chen, Dawn, Yuan, Zhengyu, White, Richard, Trias, Joaquim
Format:	Artigo
Idioma:	Inglês
Publicat:	American Society for Microbiology (ASM) 2000
Matèries:	Mechanisms of Resistance
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89968/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10858337/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.7.1825-1831.2000
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