Peptide Deformylase in Staphylococcus aureus: Resistance to Inhibition Is Mediated by Mutations in the Formyltransferase Gene

Peptide deformylase, a bacterial enzyme, represents a novel target for antibiotic discovery. Two deformylase homologs, defA and defB, were identified in Staphylococcus aureus. The defA homolog, located upstream of the transformylase gene, was identified by genomic analysis and was cloned from chromo...

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Bibliographische Detailangaben
Hauptverfasser: Margolis, Peter S., Hackbarth, Corinne J., Young, Dennis C., Wang, Wen, Chen, Dawn, Yuan, Zhengyu, White, Richard, Trias, Joaquim
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2000
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89968/
https://ncbi.nlm.nih.gov/pubmed/10858337
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