Mutations at Four Distinct Regions of the rpoB Gene Can Reduce the Susceptibility of Helicobacter pylori to Rifamycins

The transformation of a panel of rpoB mutations (codons 525 to 586) from rifampin-resistant donor strains into Helicobacter pylori 2802A confirmed the MICs associated with the respective mutations. RpoB V149X random mutations were generated and induced different levels of resistance, depending on th...

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Detalhes bibliográficos
Main Authors: Heep, Markus, Odenbreit, Stefan, Beck, Daniela, Decker, Jochen, Prohaska, Elke, Rieger, Ulrich, Lehn, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Mechanisms of Resistance
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC89941/
https://ncbi.nlm.nih.gov/pubmed/10817737
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