Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir

The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and the drugs in the combination, (ii) have knowledge of how the drugs interact (synergy, antagonism, and...

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Publicado en:	Antimicrob Agents Chemother
Autores principales:	Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., Rogers, M., Prince, W., Bye, A., Bilello, J. A.
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 2000
Materias:	Pharmacology
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89928/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1655-1659.2000
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