Use of Drug Effect Interaction Modeling with Monte Carlo Simulation To Examine the Impact of Dosing Interval on the Projected Antiviral Activity of the Combination of Abacavir and Amprenavir

The delineation of optimal regimens for combinations of agents is a difficult problem, in part because, to address it, one needs to (i) have effect relationships between the pathogen in question and the drugs in the combination, (ii) have knowledge of how the drugs interact (synergy, antagonism, and...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Drusano, G. L., D'Argenio, D. Z., Preston, S. L., Barone, C., Symonds, W., LaFon, S., Rogers, M., Prince, W., Bye, A., Bilello, J. A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89928/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1655-1659.2000
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