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Mild Heating of Amphotericin B-Desoxycholate: Effects on Ultrastructure, In Vitro Activity and Toxicity, and Therapeutic Efficacy in Severe Candidiasis in Leukopenic Mice

Heated (20 min at 70°C) amphotericin B-desoxycholate (hAMB-DOC) was further characterized, as was another formulation obtained after centrifugation (60 min, 3000 × g), hcAMB-DOC. Conventional AMB-DOC consisted of individual micelles (approximately 4 nm in diameter) and threadlike aggregated micelles...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: van Etten, Els W. M., van Vianen, Wim, Roovers, Patty, Frederik, Peter
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89919/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817715/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1598-1603.2000
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