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Comparison of Human Immunodeficiency Virus Type 1 Pr55(Gag) and Pr160(Gag-Pol) Processing Intermediates That Accumulate in Primary and Transformed Cells Treated with Peptidic and Nonpeptidic Protease Inhibitors

Human immunodeficiency virus type 1 (HIV-1) produces two polyproteins, Pr55(Gag) and Pr160(Gag-Pol), that are cleaved into mature functional subunits by the virally encoded protease. Drugs that inhibit this protease are an important part of anti-HIV therapy. We studied the ordered accumulation of Ga...

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Bibliographic Details
Main Authors: Speck, R. Renae, Flexner, Charles, Tian, Chun-Juan, Yu, Xiao-Fang
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89883/
https://ncbi.nlm.nih.gov/pubmed/10770790
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