Inhibition of Human Rhinovirus-Induced Cytokine Production by AG7088, a Human Rhinovirus 3C Protease Inhibitor

Symptom severity in patients with human rhinovirus (HRV)-induced respiratory illness is associated with elevated levels of the inflammatory cytokines interleukin-6 (IL-6) and IL-8. AG7088 is a novel, irreversible inhibitor of the HRV 3C protease. In this study, AG7088 was tested for its antiviral ac...

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Bibliographic Details
Main Authors: Zalman, L. S., Brothers, M. A., Dragovich, P. S., Zhou, R., Prins, T. J., Worland, S. T., Patick, A. K.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC89850/
https://ncbi.nlm.nih.gov/pubmed/10770757
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