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Single-Dose Pharmacokinetics and Safety of the Oral Antiviral Compound Adefovir Dipivoxil in Children Infected with Human Immunodeficiency Virus Type 1

The acyclic phosphonate analog adefovir is a potent inhibitor of retroviruses, including human immunodeficiency virus (HIV) type 1, and, unlike some antiviral nucleosides, does not require the initial phosphorylation step for its activity. Two oral dosages of the adefovir prodrug adefovir dipivoxil...

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Published in:Antimicrob Agents Chemother
Main Authors: Hughes, Walter T., Shenep, Jerry L., Rodman, John H., Fridland, Arnold, Willoughby, Rodney, Blanchard, Suzette, Purdue, Lynette, Coakley, Dion F., Cundy, Kenneth C., Culnane, Mary, Zimmer, Bonnie, Burchett, Sandra, Read, Jennifer S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2000
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89810/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10722509/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.4.1041-1046.2000
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