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Pentamidine Inhibition of Group I Intron Splicing in Candida albicans Correlates with Growth Inhibition

We previously demonstrated that pentamidine, which has been clinically used against Pneumocystis carinii, inhibits in vitro a group I intron ribozyme from that organism. Another fungal pathogen, Candida albicans, also harbors a group I intron ribozyme (Ca.LSU) in the essential rRNA genes in almost h...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Miletti, Karl E., Leibowitz, Michael J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2000
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89798/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10722497/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.4.958-966.2000
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