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Pharmacokinetics of SCH 56592, a New Azole Broad-Spectrum Antifungal Agent, in Mice, Rats, Rabbits, Dogs, and Cynomolgus Monkeys

SCH 56592 is a new broad-spectrum azole antifungal agent that is in phase 3 clinical trials for the treatment of serious systemic fungal infections. The pharmacokinetics of this drug candidate were evaluated following its intravenous (i.v.) or oral (p.o.) administration as a solution in hydroxypropy...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Nomeir, Amin A., Kumari, Pramila, Hilbert, Mary Jane, Gupta, Samir, Loebenberg, David, Cacciapuoti, Anthony, Hare, Roberta, Miller, George H., Lin, Chin-Chung, Cayen, Mitchell N.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89754/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681346/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.727-731.2000
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