Enzymes Catalyzing the Early Steps of Clavulanic Acid Biosynthesis Are Encoded by Two Sets of Paralogous Genes in Streptomyces clavuligerus

Genes encoding the proteins required for clavulanic acid biosynthesis and for cephamycin biosynthesis are grouped into a “supercluster” in Streptomyces clavuligerus. Nine open reading frames (ORFs) associated with clavulanic acid biosynthesis were located in a 15-kb segment of the supercluster, incl...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Jensen, Susan E., Elder, Kenneth J., Aidoo, Kwamena A., Paradkar, Ashish S.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2000
Soggetti:	Chemistry; Biosynthesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89753/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10681345/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.3.720-726.2000
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