Toxicity of LY303366, an Echinocandin Antifungal, in Mice Pretreated with Glucocorticoids

LY303366 is a semisynthetic derivative of the echinocandin class. During preclinical studies, lethal toxicity was observed in DBA/2 mice pretreated with a cortisone acetate dose followed by treatment with LY303366 at doses ranging from 12.5 to 50 mg/kg of body weight/day given intraperitoneally (i.p...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Clemons, Karl V., Sobel, Raymond A., Stevens, David A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Experimental Therapeutics
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89686/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639365/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.2.378-381.2000
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