Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors

The increasing incidence of life-threatening fungal infections has driven the search for new, broad-spectrum fungicidal agents that can be used for treatment and prophylaxis in immunocompromised patients. Natural-product inhibitors of cell wall (1,3)-β-d-glucan synthase such as lipopeptide pneumocan...

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Autori principali: Onishi, J., Meinz, M., Thompson, J., Curotto, J., Dreikorn, S., Rosenbach, M., Douglas, C., Abruzzo, G., Flattery, A., Kong, L., Cabello, A., Vicente, F., Pelaez, F., Diez, M. T., Martin, I., Bills, G., Giacobbe, R., Dombrowski, A., Schwartz, R., Morris, S., Harris, G., Tsipouras, A., Wilson, K., Kurtz, M. B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC89685/
https://ncbi.nlm.nih.gov/pubmed/10639364
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