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Characterization of the Antiviral Effect of 2′,3′-Dideoxy-2′, 3′-Didehydro-β-l-5-Fluorocytidine in the Duck Hepatitis B Virus Infection Model

A novel l-nucleoside analog of deoxycytidine, 2′,3′-dideoxy-2′,3′-didehydro-β-l-5-fluorocytidine (β-l-Fd4C), was recently shown to strongly inhibit hepatitis B virus (HBV) replication in the 2.2.15 cell line. Therefore, its antiviral activity was evaluated in the duck HBV (DHBV) infection model. Usi...

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Autori principali: Le Guerhier, Franck, Pichoud, Christian, Guerret, Sylviane, Chevallier, Michèle, Jamard, Catherine, Hantz, Olivier, Li, Xiu-Yan, Chen, Shu-Hui, King, Ivan, Trépo, Christian, Cheng, Yung-Chi, Zoulim, Fabien
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC89636/
https://ncbi.nlm.nih.gov/pubmed/10602731
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