Determination of Zidovudine Triphosphate Intracellular Concentrations in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Individuals by Tandem Mass Spectrometry

Nucleoside reverse transcriptase inhibitors (NRTIs) used against the human immunodeficiency virus (HIV) need to be activated intracellularly to their triphosphate moiety to inhibit HIV replication. Intracellular concentrations of these NRTI triphosphates, especially zidovudine triphosphate (ZDV-TP),...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Font, Eva, Rosario, Osvaldo, Santana, Jorge, García, Hermes, Sommadossi, Jean-Pierre, Rodriguez, Jose F.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1999
Schlagworte:	Pharmacology
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89595/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10582890/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.43.12.2964
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