Determination of Zidovudine Triphosphate Intracellular Concentrations in Peripheral Blood Mononuclear Cells from Human Immunodeficiency Virus-Infected Individuals by Tandem Mass Spectrometry

Nucleoside reverse transcriptase inhibitors (NRTIs) used against the human immunodeficiency virus (HIV) need to be activated intracellularly to their triphosphate moiety to inhibit HIV replication. Intracellular concentrations of these NRTI triphosphates, especially zidovudine triphosphate (ZDV-TP),...

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Autores principales: Font, Eva, Rosario, Osvaldo, Santana, Jorge, García, Hermes, Sommadossi, Jean-Pierre, Rodriguez, Jose F.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1999
Materias:
Pharmacology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC89595/
https://ncbi.nlm.nih.gov/pubmed/10582890
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